Symbol
Name
ID

Stat5b
signal transducer and activator of transcription 5B
MGI:103035

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level
Disease(s) Associated with STAT5B	Increased circulating IgE level
growth hormone insensitivity syndrome with immune dysregulation 2

Mouse Phenotypes

abnormal neutrophil differentiation

decreased T cell proliferation

decreased thymocyte number

enlarged spleen

abnormal leukopoiesis

abnormal double-negative T cell morphology

anemia

hypochromic microcytic anemia

decreased erythroid progenitor cell number

abnormal proerythroblast morphology

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

decreased mean corpuscular hemoglobin

increased red blood cell distribution width

anisocytosis

microcytosis

poikilocytosis

decreased neutrophil cell number

abnormal lymphocyte cell number

decreased NK cell number

abnormal T cell subpopulation ratio

decreased CD8-positive, alpha-beta T cell number

decreased lymphocyte cell number

decreased monocyte cell number

decreased leukocyte cell number

reticulocytosis

abnormal lymphocyte morphology

decreased splenocyte number

abnormal neutrophil physiology

impaired natural killer cell mediated cytotoxicity

Availability

Mouse Genotype

Stat5b^tm1Hwd/Stat5b^tm1Hwd

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Lck-cre)I57Jxm/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Tek-cre)1Ywa/0 (conditional)

Stat5b^tm1Mam/Stat5b^tm1Mam
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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